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Optimization of magnetic nanoparticle-assisted lentiviral gene transfer.

Trueck C, Zimmermann K, Mykhaylyk O, Anton M, Vosen S, Wenzel D, Fleischmann BK, Pfeifer A

Targeting of specific cells and tissues is of great interest for clinical relevant gene- and cell-based therapies. We use magnetic nanoparticles (MNPs) with a ferrimagnetic core (Fe(3)O(4)) with different coatings to optimize MNP-assisted lentiviral gene transfer with focus on different endothelial cell lines.Read more...

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